Fig. 2: Structure of RSV L in complex with MRK-1. | Communications Biology

Fig. 2: Structure of RSV L in complex with MRK-1.

From: Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Fig. 2

a The structure of RSV Ltrunc-P in complex with the MRK-1 ligand (PDB ID: 8FPI). The RdRp and PRNTase domains are in blue and green, respectively, and the P tetramer is in pink. A magnified view of MRK-1 and its binding pocket are shown. b Magnified view of the MRK-1 binding pocket with L side chains shown as green sticks. Ile1381 is shown in pink and the HR motif in orange. c Comparison of the binding site between MRK-1 bound and apo RSV polymerase structures (PDB IDs: 8FPI and 6PZK, respectively). The MRK-1 liganded structure is superimposed on the apo L structure. The apo RSV L structure is shown in gray, with the MRK-1 bound structure shown in green. Rearrangements are indicated with black arrows.

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