Fig. 3: Comparison of MRK-1 binding in RSV and HMPV polymerases. | Communications Biology

Fig. 3: Comparison of MRK-1 binding in RSV and HMPV polymerases.

From: Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Fig. 3

a Aligned electron density maps of MRK-1 bound in the RSV and HMPV polymerases (PDB IDs: 8FPI and 8FPJ, respectively). b Comparison of the binding site between MRK-1 bound RSV (protein side chains in green, compound in gray) and HMPV (protein side chains in brown, compound in light blue) L structures (PDB IDs: 8FPI and 8FPJ, respectively). Labeled residues have undergone similar structural rearrangement in both RSV and HMPV L proteins upon MRK-1 binding.

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