Fig. 4: Transcriptomic analysis and development enrichment.
From: Atypical functional connectivity hierarchy in Rolandic epilepsy
a Gene expression decoding of disease × age interaction. Statistic value in the left hemisphere. b A weighted gene expression map of regional PLS1 scores in the left hemisphere. c A scatterplot of regional PLS1 scores (a weighted sum of 10,027 gene expression scores) and disease × age interaction (Pearson’s r (146) = 0.44, pspin < 0.0001) (bottom). d We identified a gene set (n = 1627 genes) that showing consistent whole-brain expression pattern. These genes were input to a developmental enrichment analysis, showing strong associations with the cortex, thalamus, and cerebellum during the childhood-to-adolescence time window. e Enriched ontology terms in GO (gene ontology): biological process, GO: cellular component, and disease for the gene set. The size of the circle represents the number of genes involved in each term.
