Fig. 2: CNV-lncRNA developmental coexpression modules related to CAKUT and kidney development.
a Heatmap shows Pearson correlation coefficient (r) between 49 developmental coexpression modules and sample traits (Sex and developmental stage). Only significant correlation (|r | ≥ 0.5, Padj < 0.05) are labeled. The colors represent correlation coefficient value and direction (Supplementary Data 2). b Distribution of CAKUT genes (n = 172) in the developmental coexpression modules are shown in the bar plot. The y axis represents different CNV-lncRNA coexpression modules, and the x axis shows CAKUT gene counts in each module (Supplementary Data 2). c Two developmental stage-correlated modules that significantly enriched CAKUT gene sets (PH < 0.05, PH represents hypergeometric P value) are shown (CAKUT_sig1 and CAKUT_sig2). Protein coding gene (including CAKUT gene) counts and CNV-lncRNA counts in each module are shown in black and red font, respectively. Significant enrichment is indicated with the PH value in red font. Protein coding genes that went for WGCNA (n = 19957) were used as the background gene list (Supplementary Data 2). d Functional annotations of two modules that enriched genes are shown. For each module, the top seven (ranked by Padj) and organ development-associated functional annotations are shown (CAKUT_sig2 module only significantly enriched in three GO terms). GO terms that related to kidney development are in red font. The y axis represents GO terms, and the colors of the bars represent different CNV-lncRNA coexpression modules (Supplementary Data 3). The x axis displays the values of −log10(Padj). The red dashed line indicates Padj of 0.05, ** denotes Padj < 0.01 (Supplementary Data 1).
