Fig. 3: Hub CNV-lncRNAs HSALNG0134318 and HSALNG0115943 with multiple coexpressed CAKUT genes during kidney development. | Communications Biology

Fig. 3: Hub CNV-lncRNAs HSALNG0134318 and HSALNG0115943 with multiple coexpressed CAKUT genes during kidney development.

From: Integrated analysis of copy number variation-associated lncRNAs identifies candidates contributing to the etiologies of congenital kidney anomalies

Fig. 3

a The circos plot shows CAKUT-associated CNVs (n = 19), two hub CNV-lncRNAs (HSALNG0134318: MM = 0.87; HSALNG0115943: MM = 0.85) and coexpressed CAKUT genes (n = 78) in the CAKUT_sig1 module. The colors of CNVs represent the types of CNV. Two hub CNV-lncRNAs are highlighted in red font. The height of bars in the inner circos represent the mean expression level (TPM) of corresponding genes during kidney development (Supplementary Data 1, 4). b Pearson correlation coefficient between two hub CNV-lncRNAs (HSALNG0134318 and HSALNG0115943) and coexpressed CAKUT genes (n = 78) in the CAKUT_sig1 module during kidney development are shown. The colors of inner and outer circles represent Pearson correlation coefficient of CAKUT genes to HSALNG0115943 and HSALNG0134318, respectively (Supplementary Data 4, 5). c Expression patterns of two hub CNV-lncRNAs (HSALNG0134318 and HSALNG0115943, in red boxes) and predicted regulated CAKUT genes (in blue boxes) are shown (Supplementary Data 6). The numbers on x axis represents embryonic developmental stage (week). The y axis represents mean expression value of each stage. The center line represents a median value. The box limits represent upper and lower quartiles. The whiskers represent 1.5x interquartile range. The points represent outliers. Data in Fig. 4 were calculated using the human kidney developmental dataset (n = 40). MM, module membership; r, Pearson correlation coefficient (Supplementary Data 1).

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