Table 1 Main results of all the datasets analysed: mean, standard deviation, and statistical comparisons.

From: Altered brain dynamics index levels of arousal in complete locked-in syndrome

Sleep

 

Mean and standard deviation

 

Awake

N1

N2

N3

REM

mPLE

1.07 ± 0.24

1.41 ± 0.29

1.69 ± 0.31

2.45 ± 0.24

1.57 ± 0.24

mLZC

0.52 ± 0.06

0.44 ± 0.06

0.40 ± 0.06

0.29 ± 0.03

0.39 ± 0.03

cvPLE

0.39 ± 0.11

0.27 ± 0.08

0.24 ± 0.10

0.03 ± 0.03

0.05 ± 0.05

cvLZC

0.19 ± 0.03

0.20 ± 0.02

0.20 ± 0.02

0.25 ± 0.02

0.21 ± 0.01

 

p values

 

Awake vs N1

Awake vs. N2

Awake vs. N3

Awake vs. REM

N1 vs. N2

N1 vs. N3

N1 vs. REM

N2 vs. N3

N2 vs. REM

N3 vs. REM

mPLE

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.5

<0.001

<0.05

<0.001

mLZC

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

NS

<0.001

cvPLE

<0.001

<0.001

<0.001

<0.001

<0.05

<0.001

<0.05

<0.001

NS

<0.001

cvLZC

NS

NS

<0.001

NS

NS

<0.001

NS

<0.001

NS

<0.001

 

Anaesthesia

 

Mean and standard deviation

 

Pre-ketamine

Ketamine

Pre-sevoflurane

Sevoflurane

mPLE

1.16 ± 0.26

1.43 ± 0.27

1.12 ± 0.22

2.30 ± 0.40

mLZC

0.48 ± 0.07

0.42 ± 0.05

0.56 ± 0.06

0.25 ± 0.06

cvPLE

0.30 ± 0.07

0.23 ± 0.07

0.29 ± 0.05

0.14 ± 0.04

cvLZC

0.18 ± 0.04

0.20 ± 0.02

0.17 ± 0.02

0.23 ± 0.04

 

p values

 

Pre-ketamine vs. ketamine

Pre-sevoflurane vs. sevoflurane

mPLE

<0.05

<0.05

mLZC

NS

<0.05

cvPLE

NS

<0.05

cvLZC

NS

<0.05

 

Complete locked-in syndrome

 

Mean and standard deviation

 

Healthy controls

CLIS

mPLE

0.97 ± 0.40

2.11 ± 0.65

mLZC

0.55 ± 0.08

0.34 ± 0.09

cvPLE

0.44 ± 0.27

0.16 ± 0.04

cvLZC

0.16 ± 0.04

0.22 ± 0.04

 

p values

 

HC vs. CLIS

mPLE

<0.001

mLZC

<0.001

cvPLE

<0.001

cvLZC

<0.05

 

3 CLIS patients–multisession

 

Mean and standard deviation

CLIS P#6

CLIS P#9

CLIS P#11

mPLE

2.07 ± 0.21

1.85 ± 0.17

1.17 ± 0.08

mLZC

0.34 ± 0.03

0.37 ± 0.03

0.50 ± 0.02

cvPLE

0.22 ± 0.06

0.20 ± 0.02

0.27 ± 0.03

cvLZC

0.29 ± 0.03

0.25 ± 0.02

0.18 ± 0.01

 

p values

 

P#6 vs. P#9 vs. P#11

mPLE

<0.001

mLZC

<0.001

cvPLE

<0.001

cvLZC

<0.001

 

Amyotrophic lateral sclerosis

 

Mean and standard deviation

Healthy controls

non-LIS

LIS

CLIS

mPLE

0.86 ± 0.24

0.73 ± 0.29

0.86

1.97 ± 0.03

mLZC

0.56 ± 0.06

0.60 ± 0.08

0.62

0.36 ± 0.03

cvPLE

0.41 ± 0.12

0.47 ± 0.14

0.40

0.21 ± 0.01

cvLZC

0.15 ± 0.02

0.13 ± 0.02

0.16

0.28 ± 0.02

 

p values

z scores

Healthy controls vs. nonLIS

LIS

CLIS 1

CLIS 2

mPLE

NS

<1.96

>1.96

>1.96

mLZC

NS

<1.96

>1.96

>1.96

cvPLE

NS

<1.96

<1.96

<1.96

cvLZC

<0.05

<1.96

>1.96

>1.96

 

CLIS—non-LIS

 

Mean and standard deviation

CLIS 1

Non-LIS

mPLE

1.56 ± 0.43

0.64 ± 0.09

mLZC

0.47 ± 0.10

0.61 ± 0.02

cvPLE

0.37 ± 0.17

0.63 ± 0.16

cvLZC

0.28 ± 0.06

0.14 ± 0.01

 

p values

CLIS 1 vs. nonLIS

mPLE

<0.001

mLZC

<0.001

cvPLE

<0.001

cvLZC

<0.001

  1. NS not significant.
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