Fig. 2: Fatty acid composition in PE, but not in PC, is altered by PAE in the motor cortex. | Communications Biology

Fig. 2: Fatty acid composition in PE, but not in PC, is altered by PAE in the motor cortex.

From: Fatty acid metabolism changes in association with neurobehavioral deficits in animal models of fetal alcohol spectrum disorders

Fig. 2

a PAE mice show an increase in abundance of 36:4 of PE (16:0/20:4) compared to control mice (p = 0.0096) in the motor cortex at P30. Inset shows the magnified view of the fatty acid species that are less abundant. b Multi reaction monitoring (MRM) analysis reveals a decrease of 26:6 of PE fatty acid in PAE motor cortex compared to control (p = 0.0397). No interaction between fatty acid species and prenatal exposure types by two-way ANOVA. Bonferroni’s multiple comparisons tests were used as post hoc tests. Control (PBS exposure) n = 4, PAE n = 4. *,**p < 0.05, 0.01. PE phosphatidylethanolamine. c, d There is no difference in abundance of fatty acid species between control and PAE in PC of the motor cortex at P30. Two-way ANOVA found no interaction between fatty acid species and exposure types. Control n = 4, PAE n = 4. Inset shows the magnified view of the fatty acid species that are less abundant. Graphs represent mean ± SEM. Each dot represents an individual animal. PC phosphatidylcholine.

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