Fig. 8: SERF1a is elevated in HD transgenic mice brain, HD iPSCs, and HD plasma. | Communications Biology

Fig. 8: SERF1a is elevated in HD transgenic mice brain, HD iPSCs, and HD plasma.

From: Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity

Fig. 8

a The SERF1a transcript level in whole brain of HD transgenic mice and wild-type littermate was analyzed by Q-PCR. b The SERF1a transcript level in human HD and control iPSC cells was analyzed by Q-PCR. Data were analyzed by one-way ANOVA, *P < 0.05, ***P < 0.001; n = 3. The error bars represent standard deviation. c SERF1a level is significantly higher in plasma of HD comparing to that in the normal control. Spike-in plasma was used as a standard to calculate SERF1a concentration. Normal plasma, n = 18; HD plasma, n = 18. Data were analyzed by unpaired Student’s t-test, ***P < 0.001. The error bars represent standard deviation.

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