Fig. 2: Insulin resistance, insulin and estrogen signaling related genes and diseases.
From: Spaceflight induces changes in gene expression profiles linked to insulin and estrogen
a Heatmap for 56 out of 145 common genes across the insulin resistance and insulin signaling pathways for which there were gene expression values across all nine tissues. b Disease enrichment plot showing top 10 diseases from mouse genome database (MGD) being enriched using 145 unique genes common across insulin resistance, insulin signaling and estrogen signaling. The y axis shows the disease labels and the x axis shows the ratio of disease relevant genes to the total number of genes found from the 145 genes that were present in MGD. The dots in the enrichment plots are colored by the FDR values and the sizes of the dots indicate the number of genes found to be enriched for a disease. Diabetes and fatty liver are the top two enriched diseases which are related to estrogen and insulin signaling. c Disease enrichment plot is shown with top 10 diseases from human curated sources (e.g., UniProt, ClinGen) using species relevant genes out of 145 genes from the NCBI list. Obesity and fatty liver are the top two enriched diseases which are also related to estrogen and insulin signaling.
