Fig. 7: Ancestral reconstruction of the ACGT motif patterns across H. pylori major phylogeographic populations.
From: Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori
A time-scaled tree was created using 40 representative strains from the hpAfrica1, hpAfrica2, hpEastAsia, and hpAsia2 populations. The ancestral states for each genomic position displaying ACGT motifs in modern strains were first predicted separately by stochastic character mapping and then concatenated to generate the ancestral patterns. A graphical representation of the ACGT motif patterns is given by boxes located at each ancestral node. Green squares represent new individual ACGT motifs, while red and orange squares indicate ACGT motifs lost through ATGT/ACAT mutations and other mutations, respectively.
