Fig. 2: Kaempferol and structurally related compounds potentiate the antimicrobial activity of colistin. | Communications Biology

Fig. 2: Kaempferol and structurally related compounds potentiate the antimicrobial activity of colistin.

From: Disrupting iron homeostasis can potentiate colistin activity and overcome colistin resistance mechanisms in Gram-Negative Bacteria

Fig. 2

a Chemical structures of kaempferol and kaempferol-like molecules. b Impact of kaempferol derivatives at a concentration of 0.05 mM on the growth of A. baumannii. The native structure of kaempferol has the highest potentiating activity against A. baumannii when combined with sub-MIC amounts of colistin (1.22 µg/mL). For (b), assays were carried out in biological triplicate, with three technical repeats. Statistical analysis consisted of one-way ANOVA between the treated sample and the DMSO carrier control. Average values ± S.D. are represented. Significance is indicated as ns = non-significant, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.

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