Fig. 3: Kaempferol and structurally related compounds inhibit biofilm formation. | Communications Biology

Fig. 3: Kaempferol and structurally related compounds inhibit biofilm formation.

From: Disrupting iron homeostasis can potentiate colistin activity and overcome colistin resistance mechanisms in Gram-Negative Bacteria

Fig. 3

a Impact of kaempferol-like compounds at a concentration of 0.05 mM on A. baumannii biofilm formation. The native structure of kaempferol, along with some of its derivatives, have activity against A. baumannii biofilms when applied as a monotherapy. b Minimum biofilm inhibitory concentration (MBIC) of kaempferol on A. baumannii. Complete biofilm inhibition was observed at a concentration of 0.3 mM, and inhibition is shown to be dose dependent. For all panels, assays were carried out in biological triplicate, with three technical repeats. Analysis consists of one-way ANOVA for (a) and two-way ANOVA for (b), between the treated samples and the DMSO carrier control. Significance is indicated as ns = non-significant, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.

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