Fig. 7: Unique residues contribute to proton gating of TadNaC2. | Communications Biology

Fig. 7: Unique residues contribute to proton gating of TadNaC2.

From: Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

Fig. 7

a–c Average pH dose–response curves ± standard deviation for wild-type (wt) TadNaC2 and variants bearing amino acid substitutions within the wrist (a), finger (b), and palm (c) regions. d, e Plot of average ± standard deviation pH50 (d) and normalized peak current amplitude (e) for wild-type (wt) and various point mutated TadNaC2 channels. Red-colored asterisks denote p value thresholds for two-sample t-tests comparing wild-type to mutant values. f Sample whole-cell currents of wild-type TadNaC2 and select mutant variants.

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