Table 1 Chemical structure of compounds and their in vitro inhibition properties.
From: Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Inhibitor | SARS-CoV-2 Mpro Ki [nM] | CatB Ki [nM] | CatK Ki [pM] | CatL Ki [pM] | CatV Ki [pM] | VERO E6 EC50 [nM] |
|---|---|---|---|---|---|---|
| 4500 (3900–5600) | 41 ± 7/27–54 | 61 ± 12/37–85 | 131 ± 21/90–172 | 361 ± 47/268–454 | 183 ± 65 |
| 4700 (1100–8000) | 70 ± 15/39–100 | 50 ± 12/28–73 | 148 ± 19/111–185 | 169 ± 18/133–204 | 120 ± 54 |
| <100 [40]a | 163 ± 50/63–262 | 91 ± 11/70–112 | 259 ± 27/204–314 | 242 ± 23/196–288 | 1071 ± 278 |
