Table 2 Definitions of epitopic sites (ES) seen by Abs and Nbs.

ES	RBD residue (range)	Amino acid sequence	Structural feature	ASA (Å²)	Abs (H chain) (%)	Nbs (%)
1	339–341	GEV	α-helix	155	0.78	0.16
2	343–349	NATRFAS	loop	455	4.07	2.83
3	351–357	YAWNRKR	3₁₀ ->β-strand	410	2.60	3.76
4	368–374	LYNSASF	α-helix->loop	469	3.17	7.03
5	375–380	STFKCY	β-strand	287	2.90	6.97
6	381–386	GVSPTK	Loop->3₁₀	381	2.49	5.50
7	403–409	RGDEVRQ	3₁₀	321	2.76	4.68
8	411–417	APGQTGK	loop	342	4.91	2.78
9	420–428	DYNYKLPDD	α-helix->loop	371	3.24	1.69
10	437–443	NSNNLDS	β-strand->α-helix	378	3.59	1.47
11	444–449	KVGGNY	loop/strand	457	7.10	8.39
12	450–454	NYLYR	β-strand	194	4.57	5.72
13	455–460	LFRKSN	loop	448	9.98	4.25
14	462–467	KPFERD	loop	470	1.28	1.31
15	468–472	ISTEI	loop	384	2.44	4.47
16	473–479	YQAGSTP	β-strand->loop	466	9.34	0.71
17	481–484	NGVE	loop	404	4.36	5.28
18	485–487	GFN	loop	275	7.06	3.65
19	488–491	CYFP	β-strand->loop	181	5.98	5.88
20	492–496	LQSYG	β-strand	126	7.15	9.69
21	497–502	FQPTNG	loop	307	3.38	2.94
22	503–509	VGYQPYR	3₁₀->β-strand	253	2.42	4.14
23	516–520	ELLHA	loop	548	0.44	1.20

RBD residue range for each ES is indicated, along with the amino acid sequence, secondary structural features (as determined by DSSP⁷⁸), accessible surface area (ASA) (see Methods) of the contacting residues, and percentage of Ab H chains and Nbs.

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