Table 4 Relation of ES to SARS2-CoV-2 escape mutations.

From: SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain

Variant

Alpha

Beta

Delta

Omicron

Sub (X)

ES

Mutations

   

G339X

D,H

1

   

R346X

T,K,E,I,S

2

   

S371L

 

4

   

S375F

 

4

   

T376A

 

5

   

D405N

 

7

 

K417N

K417N*

K417X

N,T,D

8

   

N440K

 

10

   

L441K

 

10

   

K444X

T,R,N,M,G

11

   

V445X

A,P,N

11

   

G446X

D,S,Y

11

  

L452R

L452X

Q,R,M

12

   

F456L**

 

13

   

N460X

K,S,Y

13

   

S477N

 

16

  

T478K

T478X

K,R

16

E484K*

E484K

 

E484A

 

17

   

F486X

I,V,P,S,A

18

   

Y489L

 

19

   

F490X

I,L,S,V,C,R,Q

19

   

R493X

Q,L,P

19

S494P*

    

20

   

G496S

 

20

   

Q498R

 

21

N501Y

N501Y

 

N501Y

 

21

   

Y505H

 

22

  1. Major mutations with the main lineage of variants of SERS-Cov-2 and corresponding ES site. “X” column indicates the amino acid substitutions of the subvariants of Omicron. (*mutations found in some but not all indicated variants, i.e. nonsignature mutations; **Latest mutation of Omicron, as July 2023, EG.5 = XBB.1.9.2.5, it appears in ES13).
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