Fig. 2: Effective connectivity results and their relationship with pupillary response.

a–c PEB results of the DCM analysis at baseline, and under blue-enriched or orange light modulation, respectively. Left: matrices of the effective connectivity either at baseline (a) or with modulatory effects exerted by the active blue-enriched (b) or the control orange (c) light for either the left or the right hemisphere. Right: schematic representation of the corresponding matrices where IPS and the thalamus are showed in green and yellow respectively. On all panels, only suprathreshold parameters are shown (Pp > 0.95) whereas subthreshold parameters are marked as “n.s” (i.e., non-suprathreshold). Connections strengths are represented on a scale from turquoise to yellow, if excitatory, and from light to dark blue if inhibitory. Non modeled direct effects (i.e., whose priors were set to 0) are displayed in white. In the schematic representation, the line patterns denote whether the connection was significantly modulated compared to baseline: solid and dashed lines represent connections that were significantly modulated or not, respectively; red lines denote excitatory connections whereas black ones denote inhibitory connections. d Spearman correlation results. Spearman correlation between modulation exerted by blue-enriched light over the TH-IPS connection (referenced to baseline) across both hemispheres and the difference in pupil constriction in both lights exposures (r[9] = −0.82; p = 0.0037). Density plots for both variables are also provided in orange and red respectively.