Fig. 1: GSDMC expression is decreased in OLP. | Communications Biology

Fig. 1: GSDMC expression is decreased in OLP.

From: METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC

Fig. 1

a GSDMC mRNA levels in oral epithelial layers from healthy or diseased tissues determined by real-time PCR, n = 14. Western blot (b) and densitometric analysis (c) showing GSDMC protein levels in oral epithelial layers from healthy or diseased tissues, n = 14. Data (b) are representative of 14 samples. GSDMC mRNA or protein expression detected by real-time PCR (d), western blot (e) or densitometric quantitation (f) in HOKs with or without 12-hour LPS treatment (100 ng/ml), n = 3. Data (e) are representative of 3 samples. GSDMC mRNA or protein levels measured by real-time PCR (g), western blot (h) or densitometric quantitation (i) in HOKs with or without 12-hour activated CD4+ T cells treatment, n = 3. Data (h) are representative of 3 samples. **P < 0.01, ***P < 0.001 vs corresponding health or control group; Ctrl, control. Data were expressed as means ± standard deviation. All experiments were carried out at least 3 times. Student’s t test (a, c, d, f, g and i) was performed for the statistical analysis.

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