Fig. 2: COMF candidates nominated by METIS.
From: Mining cancer genomes for change-of-metabolic-function mutations
a CBL mutational distribution in COSMIC v59 showing recurrent Y371H mutations. b Multiple alignment with Y371 shown in red. c Structure of human CBL-UBCH7 complex (PDB: 1FBV) with Y371 shown in red, other recurrently-mutated residues shown in orange, and ligands shown in stick representations. d WBSCR17 mutational distribution in COSMIC v59 showing recurrent R228C mutations. e Homology alignment for WBSCR17 with R228 shown in red. f Structure of mouse homolog of WBSCR17 (PDB: 1XHB) with R228 in active site pocket shown in green. g SLC17A5 mutational distribution in COSMIC v59 with recurrent R364C mutations. h Multiple alignment of SLC17A5 R364 region with R364 shown in red. i OGDHL mutational distribution in COSMIC v59 with recurrent A400T mutations shown. j Multiple alignment of OGDHL with A400 shown in red. k Structure of SucA domain of Mycobacterium smegmatis alpha-ketoglutarate decarboxylase in complex with acetyl-CoA (PDB: 2XTA) with residue homologous to A400 shown in red with ligand shown in stick representation. Primary enzymatic function domains are represented by red boxes while secondary functions are represented by green boxes underneath the mutation plot.
