Fig. 4: Comparisons between candidate COMF metabolomes and WT controls.
From: Mining cancer genomes for change-of-metabolic-function mutations
Volcano plots show fold-change (x-axis) and p-value (Welch’s t-test, y-axis) for biochemical abundance in cells expressing each mutant (n = 3 biological replicates) compared to the respective wild type (WT) controls (n = 3 biological replicates). a CBL Y371H (MUT) vs. wild type (WT); b WBSCR17 (MUT) vs. wild type (WT)R228C; c SLC17A5 R364C (MUT) vs. wild type (WT); d OGDHL A400T (MUT) vs. wild type (WT). Biochemicals are colored based on metabolic super pathway. Significant metabolites increased in the mutant group (P < 0.05, Welch’s t test, without FDR correction) and select metabolites increased in the WT groups are called out.
