Fig. 6: COMF enzymatic candidates nominated by METIS2.
From: Mining cancer genomes for change-of-metabolic-function mutations
a DAO mutational distribution in COSMIC v96 showing recurrent R283W mutations. b Multiple alignment with R283 shown in red. c Predicted structure of human DAO complex with R283 highlighted. d–f Same for MICAL2-L99F. g–i Same for SMPD3-D638A. j–l Same for SMPD3-H639P. Primary enzymatic function domains are represented by red boxes while secondary functions are represented by green boxes underneath the mutation plot. Enzymes without currently defined domains are annotated as such.
