Fig. 6: Scheme illustrating the Vertex model. | Communications Biology

Fig. 6: Scheme illustrating the Vertex model.

From: The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction

Fig. 6

a Cylindrical representation of the tissue structure, where R is the radius and A the apical orientation of the cell sheet, respectively. b Apical view of the simulated epithelia. Wild-type cells are represented in red, whereas E-cadherin mutant cells are indicated in yellow. In this open representation of the cylindrical geometry of the tissue, V corresponds to the centre of the simulation domain and D (in green) corresponds to the boundaries. Periodic boundary conditions are implemented in the four boundaries of the domain, indicated by the blue asterisks.

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