Table 1 Parameters adopted in the phase-field model.

From: The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction

Parameter

Symbol

Value

 

Lattice size

ϵ

1.0 μm

 

Average cell diameter

 

15 μm

 

Cell Volume

Vtarget

1.7 × 103 μm3

 

Membrane tension

σ

1.0 × 10−5 N/m

63,64,65,66

Interface energy coeff.

κ

85 J/m3

\(\kappa =\frac{6\sigma \sqrt{2}}{\epsilon }\)

Hard-core repulsion coeff.

γ

14 J/m3

Estim.

Mobility

M

5.3 m3J−1s−1

Fit to exp.

Volume conservation coeff.

αV

14 J/m6

Estim.