Fig. 3: Dynein inhibition prevents AβO-induced synaptic proteasome mislocalization in hippocampal cultures. | Communications Biology

Fig. 3: Dynein inhibition prevents AβO-induced synaptic proteasome mislocalization in hippocampal cultures.

From: Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Fig. 3

a–c Primary hippocampal cultures were exposed to vehicle or 0.5 µM AβOs for 24 h in the presence or absence of erythro-9-[3-(2-hydroxynonyl)]adenine (EHNA; 100 µM), and were then immunolabeled for proteasome 20S subunit α1 (a). Quantification of dendritic (b) or cell body (c) immunoreactivities (n = 4 independent cultures; two-tailed two-way ANOVA with Holm-Sidak post hoc test). Data are presented as mean ± SEM. Scale bar: 20 µm.

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