Fig. 1: Gross morphology and in vivo functionality.

a Echocardiographic measurements of representative valves at implantation, and after 6 and 12 months follow up. b Schematic orientation of the heart valve prosthesis. RCL right coronary leaflet, NCL non coronary leaflet, LCL left coronary leaflet. c macroscopic images of one representative valve for 3, 6, 9 and 12 months follow-up. Left image is the intact valve from aortic view, middle image are the dissected leaflets from ventricular view, right are histological slices of a valve leaflet stained with H&E. Scale bar is 1 mm.