Fig. 3: Subpopulations of ILC2s are enriched with different molecular signatures indicating diverse cellular functions.
From: A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion
A Dotplots indicate different gene sets being enriched in each subpopulation/cluster. Molecular Signature Database Hallmark gene sets are used as reference. Numbers in parenthesis indicate the number of overexpressed genes from each cluster that are overrepresented in the corresponding pathway. B Expression of selected ILC2 markers-of-interest (GOIs) are differentially expressed by different clusters. Dotplot shows marker-of-interest expression per cluster. Color intensity indicates log-scaled mean gene expression level. Dot size indicates the fraction of cells in the cluster for each gene. C Intracellular staining for granzymes B & C: a portion of ta-ILC2s are positive for both (10.4%), but mostly for granzyme B (60.9%). A fraction of ta-ILC2s is positive for intracellular IFITM1 (1.4%) confirmed by flow cytometry.
