Fig. 1: Fast twitching EDL muscle displays age-related changes with unaffected switch. | Communications Biology

Fig. 1: Fast twitching EDL muscle displays age-related changes with unaffected switch.

From: Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging

Fig. 1

A The graph represents the percentage of Myosin-heavy chain (Myh) in young and old EDL muscle (on the left), where beige, red, gray and orange represent Myh4, Myh2, Myh1, and Myh7 (the latter not graphically represented), respectively. The graphics on the right panel represent the different Myh gene expression levels, validated by quantitative PCR (n = 6–8 per group). B The H&E staining shows the cross-section EDL from young (upper image) and old (bottom image) mice, the latest with damaged fibers (black arrows). C The histogram shows the percentage of total fibers with different cross-sectional areas (CSA) (on the left) and on the right, the graphic represents the mean of CSA between young and old mice. D The left graphic depicts the levels of the 3-methylhistidine metabolite and on the right represents MAFbx protein levels, both show the fold change relative to young (n = 6–8). Statistical significance is given as follows *P < 0.05, **P < 0.01 (Mann–Whitney U test). Values presented as mean ± SEM; n.s. not significant.

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