Fig. 2: Non-sarcopenic mice display major downregulation of mitochondrial pathways in aged EDL muscle. | Communications Biology

Fig. 2: Non-sarcopenic mice display major downregulation of mitochondrial pathways in aged EDL muscle.

From: Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging

Fig. 2

A Gene Set Enrichment Analysis (GSEA). The left side shows the biological processes that are activated and on the right side the ones which are suppressed. The graphics on the right represent the enrichment score of GO term from mitochondrial respiratory chain complex assembly. B Schematic representation of electron transport chain with the associated genes. Downregulated genes in aged EDL related to mitochondrial complexes are highlighted in green. C Associated localization of significantly downregulated metabolites from 114 annotated metabolites. D NAD metabolism. The graphics show the fold change of NAD reduced, oxidized and the ratio between young and old EDL muscle. E Glucose metabolism. The graphic shows the levels of glucose as well as two products of glycolysis (lactate and pyruvate), between young and old muscle. F Creatine metabolism. All values are relative to the mean of young controls, except the fold change ratios. Statistical significance is given as follows *P < 0.05, **P < 0.01, ***P < 0.001 (t test). Values presented as mean ± SEM.

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