Fig. 3: Mitochondrial structure and respiration capacity are affected during EDL aging. | Communications Biology

Fig. 3: Mitochondrial structure and respiration capacity are affected during EDL aging.

From: Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging

Fig. 3

A Representative electron microscopy images of young and old EDL muscle. Few characteristics are depicted, numbered and zoomed in (n = 3 per group). B Area of tubular aggregates quantified per TEM picture as fold change relative to young (n = 3 animals per group; 8–12 pictures were analyzed per group). Values presented as mean ± SEM. C N6-carboxymethyllysine metabolite levels. Fold change relative to young. D Sarcoplasmic (SR)-related genes with Log2Fold change relative to young. E Trichrome (TC) staining. Area quantification performed with image J. Fold change relative to young. F Log2Fold change of spermidine oxidase (Smox) and spermidine metabolite. Fold change relative to young. Statistical significance is given as follows *P < 0.05, **P < 0.01 (Mann–Whitney U test). G Representative analysis of mitochondrial respiration from young and old EDL muscle. Quantification of oxygen consumption rate (OCR) in pmol/min/µg of protein (n = 5 per group). Values presented as mean ± SEM, n.s. not significant.

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