Fig. 4: Mouse EDL age-related signatures overlap with skeletal muscle human aging.

A Functional enrichment across different ages in female (left panel) and male (right panel) humans. The heatmap represents the log-fold change and each group is relative to the youngest group with ages between 20 and 29 years old. On the left the heatmap shows the downregulated biological processes, in purple, and on the right, the upregulated biological processes during aging, in orange, FDR < 0.05. B The graphics show all the downregulated (in purple) or upregulated (in orange) biological processes that are decreasing with aging (on the left part of each graphic) or increasing with aging (right part of each graphic). Each single line in the upper graphics represents the correlation of the expression of one gene during aging. The four graphics below represent the genes most positively or negatively correlated with aging in female (on the left) and in males (on the right).