Fig. 5: Lifespan-extending interventions are negatively associated with aging EDL muscle. | Communications Biology

Fig. 5: Lifespan-extending interventions are negatively associated with aging EDL muscle.

From: Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging

Fig. 5

A The graphic represents the negative and positive associations between aged EDL gene signatures and signatures of longevity interventions (left) and aging (right), respectively. P value for association with each signature was assessed using GSEA-based test. B Functional enrichment analyses (GSEA) of gene expression profile of aged EDL muscle (left), signatures of mammalian aging (middle) and signatures of lifespan-extending interventions in mice (right). Cells are colored based on the normalized enrichment score (NES). The whole list of enriched functions is in Supplementary Table S3. ^P.adjusted<0.1; *P.adjusted <0.05; **P.adjusted <0.01; ***P.adjusted <0.001.

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