Fig. 7: AFM-IR spectroscopy of droplets-seeded TDP-43PrLD fibrils. | Communications Biology

Fig. 7: AFM-IR spectroscopy of droplets-seeded TDP-43PrLD fibrils.

From: α-Synuclein emulsifies TDP-43 prion-like domain—RNA liquid droplets to promote heterotypic amyloid fibrils

Fig. 7

AFM topographs of fibrillar aggregates of (a) αS, (c) TDP-43PrLD, (e). TDP-43PrLD seeded by TDP-43PrLD-RNA droplets and (g). TDP-43PrLD seeded by αS modulated TDP-43PrLD-RNA droplets. b, d, f, h Corresponding mean IR spectra. The red-shaded regions represent the spectral standard deviations. i Second derivatives of the mean spectra. j Spectral components determined from MCR-ALS decomposition. k Weights of each of the spectral components for each fibril subtype are color-coded to the corresponding spectral component in (j). The error bars represent standard deviations between spectra of a given subtype. The units of the Z-color bar in the AFM images (a, c, e, g) is nm.

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