Fig. 2: Cellular redundancy amongst inflammasomes converges upon NLRP1 in a cell-specific manner.
From: NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise
While nigericin and dsDNA are considered prototypic NLRP3 and AIM2 in macrophages, in the absence of NLRP3 or AIM2, subsequent ribotoxic stress induces ZAKα-mediated activation of NLRP1. Created with BiorRender.com.
