Fig. 2: PARL deficiency leads to morphological defects in mitochondria.
From: The mitochondrial protease PARL is required for spermatogenesis
TEM pictures of mitochondria in Sertoli cells and spermatocytes of 8-week-old WT and Parl−/− mice (scale bars: 500 nm). WT testes show physiological mitochondria with a clear intact cristae structure in Sertoli cells (asterisks) and the typical condensed type of mitochondria in spermatocytes (arrow heads). Mitochondria of Parl−/− Sertoli cells (stars) and spermatocytes (arrows) show corruption of cristae morphology and are less electron dense. Furthermore, the mitochondria of spermatocytes display a reduction of the condensed type that is physiologically found in spermatocytes.
