Fig. 3: Homeostatic control of adaptive RBC lifespan. | Communications Biology

Fig. 3: Homeostatic control of adaptive RBC lifespan.

From: A new role for erythropoietin in the homeostasis of red blood cells

Fig. 3

a Effect of D0 on the fate and lifespan of RBCs. b Combined effect of D0 and rD on the fate and lifespan of RBCs. The black thick line represents the autoimmunity threshold. c We hypothesize that (i) the concentration of EPO during the formation of the cell determines how much CD47 it expresses when it enters the blood (D0), and (ii) the concentration of EPO during the life of the RBC controls SIRP-α expression in macrophages (rD).

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