Fig. 3: CBN hyperpolarizes 500 ms inactivation probability curve in Nav1.7, but it does not alter open-state fast-inactivation. | Communications Biology

Fig. 3: CBN hyperpolarizes 500 ms inactivation probability curve in Nav1.7, but it does not alter open-state fast-inactivation.

From: Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol

Fig. 3

a, b Representative macroscopic current traces of Veh and CBN (15 µM). c Voltage-dependence of 500 ms inactivation as normalized current plotted against membrane potential fit with single Boltzmann. d Quantification of SSI midpoints (in mV). Data shown as means ± SEM (n = 5–15). **** Indicates p < 0.0001, 15 and 30 µM compared to vehicle. e Open-state fast-inactivation time constants. Data shown as means ± SEM (n = 5–11). f The protocol that was used for e.

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