Fig. 4: CBN slows recovery from slow inactivation in Nav1.7. | Communications Biology

Fig. 4: CBN slows recovery from slow inactivation in Nav1.7.

From: Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol

Fig. 4

a Shows the protocol that was used to measure CBG effect on channel recovery from duration pre-pulses. b Recovery from inactivation in the presence of 0 (Veh)−30 µM CBN, from 20 ms, c 500 ms, and d 5 s. Symbols for data shown in panels b–d are the same. Data shown as means ± SEM (n = 10–25 for 20 ms, 9–26 for 500 ms, and 5–23 for 5 s). e, f The slow components of recovery from inactivation in vehicle and CBN at 20 ms, 500 ms, and 5 s are shown on Y axis (e), and the fraction of slow to fast component of recovery from inactivation is shown on the Y axis (f). Symbols for data shown in panels e-f are the same.

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