Fig. 8: CBN inhibits native voltage-dependent sodium currents in freshly isolated DRG neurons. | Communications Biology

Fig. 8: CBN inhibits native voltage-dependent sodium currents in freshly isolated DRG neurons.

From: Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol

Fig. 8

a The distribution of the capacitance sizes we got from our cohort of neurons. b Mean peak amplitudes of neuronal Nav currents from a holding-potential of −120 and −80 mV, in vehicle and 15 µM CBN. All measurements are matched-paired. c CBN’s potency across all neurons at −120 and −80 mV shown as fractional block. Data shown as means ± SEM (n = 41). d The two-pulse protocol that was used to measure inhibition, along with a representative trace from each of P1 and P2. e The cohort of neurons binned by capacitance sizes. Data shown as means ± SEM (n = 41). * Indicates p < 0.05, **** indicates p < 0.0001, ns indicates not significantly different p > 0.05.

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