Fig. 2: CST reduced necrosis of the femoral head in a rat model. | Communications Biology

Fig. 2: CST reduced necrosis of the femoral head in a rat model.

From: Cortistatin prevents glucocorticoid-associated osteonecrosis of the femoral head via the GHSR1a/Akt pathway

Fig. 2

a Schematic diagram illustrating the timeline of the operation process. The images and elements were created by authors. b The representative images and radiological manifestations of the femoral head in 1. The Blank group. 2. The CST group. 3. The MPS + PBS group (as a control group). 4. The MPS + CST group. 5. The MPS + CST + MK2206 group. c Micro-CT assay of 1. The Blank group. 2. The CST group. 3. The MPS + PBS group (as a control group). 4. The MPS + CST group. 5. The MPS + CST + MK2206 group. The red dashed area represents the subchondral bone, and the femoral neck is represented by a yellow dashed area. The statistical analysis of BMD (d), BV/TV (e), BS/BV (f), Tb.N (g), Tb.Th (h), and Tb.Sp (i) (n = 5 per group, data are shown as mean ± SD, ***p < 0.001, **p < 0.01, *p < 0.05).

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