Fig. 1: Proteomic analysis of industrial plasma fractionation intermediates.
a Simplified example of an industrial plasma fractionation process as applicable in the examined plasma fractionation manufacturing plant. Abbreviations used refer to Prothrombin Complex Concentrate (PCC), Coagulation factors VIII and FIX (FVIII and FIX), Antithrombin III (ATIII), Albumin (ALB) and Immunoglobulin (IgG). The entire process generates at least three unused intermediates (Fraction I, FI; Fraction III, FIII and Fraction IV1-4, FIV1-4). b Venn diagram of the proteomes of FI, FIII and FIV1-4. For the full list of unique proteins see Supplementary Data 1c. Scheme of the filtering process leading to the prioritization of unused intermediate proteins based on function and plasma proteome association, disease association, therapeutic value/potential and evidence of efficacy as protein replacement therapies. For the complete prioritization analysis see Supplementary Data 2.
