Fig. 7: Systemic effects of kCP treatment on liver, adipose tissue and erythropoiesis of cpKO mice. | Communications Biology

Fig. 7: Systemic effects of kCP treatment on liver, adipose tissue and erythropoiesis of cpKO mice.

From: New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia

Fig. 7

a ELISA evaluation of human CP in the liver of mice treated 4 months with either kCP (KO+kCP) or saline (KO, WT). b Iron quantification by ICP-MS in liver homogenates of treated mice. c Representative images of stained liver section in treated mice; magnification: 5×, scalebar: 100 µm. d Quantification of lipids macrovesicles in the liver of treated mice. e ELISA evaluation of leptin secreted by adipose tissue in the sera of mice. f–h Evaluation in the mice’s peripheral blood of representative erythropoiesis parameters relevant for ACP, namely f mean corpuscular volume (MCV), g mean corpuscular hemoglobin (MCH) and h reticulocyte hemoglobin content (RET-Hgb). Data are presented as mean ± SEM; each dot corresponds to one animal (N = 20 mice/group; N = 40 for cpKO at 6 months). Statistical p values were evaluated by one-way ANOVA followed by Tukey’s post-test c, e or Kruskal-Wallis test followed by Dunn’s post-test analysis a, b, f, g, h.

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