Fig. 8: Unsupervised multivariate analysis of the parameters measured distinguishes cpKO from WT mice and indicates the therapeutic effect of purified kCP treatment.

Principal component analysis (PCA) performed a using 13 parameters measured in the cpKO and WT mice at 6 months of age, which included the 5 parameters shown in Figs. 4–7 plus animal sex and 7 additional hematological parameters, and b using 33 parameters, which included the 13 parameters shown in the figures plus animal sex and 19 additional features measured in the mice at 10 months of age after treatment with either purified human kCP (KO+kCP) or saline (KO and WT). The results of the immunofluorescence analysis in brain were excluded because data were available for only a subset of the mice. See Supplementary Tables 1 and 2, and Supplementary Data 5 for the values of the parameters included or excluded in the analysis. Each dot represents one animal; ellipses represent the 95% confidence interval area of each group.