Fig. 2: Host genetic signals associated with nasal microbial taxa and functions.

Manhattan plot shows the genetic variants associated with the nasal microbial taxa (n = 86) and functions (n = 207). The horizontal grey and black lines represent the genome-wide (p = 5 × 10−8) and study-wide (p = 1.71 × 10−10 for 293 independent M-GWAS tests) significance levels, respectively. Seventeen loci associated with taxa and 46 loci associated with functions reaching genome-wide significance were marked in orange and blue, respectively. The top two loci, their located genes, and associated nasal taxa that reached study-wide significance were also listed.