Fig. 3: The links among human CAMK2A locus (rs73268759), the nasal genus Actinomyces, and host traits in this cohort.

a The regional plot presented the strongest association of CAMK2A variation with the genus Actinomyces (presence/absence status; p = 7.75 × 10⁻¹³). b The prevalences of the genus Actinomyces were compared between different genotyped individuals (CC vs CT/TT) according to CAMK2A (rs73268759) variation. The p-value in b was obtained using a logistic model based on the presence/absence status of the genus Actinomyces. c, d The mean relative abundances of the genus Actinomyces from the nasal (c) and gut (d) sites, compared between different genotyped individuals (CC vs CT/TT) according to CAMK2A (rs73268759) variation. The statistical comparisons in (c) and (d) denote the p-values of the linear regression analysis on log-transformed relative abundances. All analyses were performed by adjusting sex, age, BMI, sequencing reads, and the top ten PCs. e The bar plot showed associations of the CAMK2A (rs73268759) variation with host traits in this cohort. f The correlations of the genus Actinomyces with host traits in this cohort. In e, f, only associations or correlations with p < 0.05 were shown. Significant code: 0.05 * 0.01 ** 0.001. The source data for e-f was available in Supplementary Data 15.