Fig. 1: Proposed glial differentiation trajectories.
From: Gliomas: a reflection of temporal gliogenic principles
Schematized representation of proposed glial differentiation trajectories. RG are hypothesized to either (solid arrows) give rise to a bipotent glial intermediate progenitor that can generate both astrocytes and oligodendrocytes or (dashed arrows) directly generate astrocyte and oligodendrocyte lineages. Colored boxes indicate lineage markers and relevant TF drivers and inhibitors are listed next to respective lineage types. Outer radial glia (oRG), ventricular radial glia (vRG), glial intermediate progenitor cell (gIPC).
