Fig. 1: Expression of KCTD21-AS1 increased in lung cancer.

a Number of different lncRNA expression levels. b Different expression levels of some lncRNAs including KCTD21-AS1 between lung cancer and adjacent normal tissues from GSE70880. **p < 0.01, Mann–Whitney U test. Data were shown as median (interquartile range). c Results of lncRNA microarray showed the up-regulated or down-regulated genes between lung adenocarcinoma and adjacent controls. d Different expression levels of some lncRNAs from lncRNA microarray, including KCTD21-AS1. e Levels of lncRNA were detected by qRT-PCR in lung adenocarcinoma tissues and adjacent normal tissues (N = 20). Data were shown as median (interquartile range), **p < 0.01, Mann–Whitney U test. f Overall survival analysis of patients with lung adenocarcinoma. g In situ hybridization showed that KCTD21-AS1 expression in lung adenocarcinoma tissues. Red indicates the expression of KCTD21-AS1. Bar = 20 μm. h In situ hybridization detection of KCTD21-AS1 in A549 cells. Red indicates the expression of KCTD21-AS1. Bar = 20 μm.