Fig. 8: Levels of miR-519d-5p and its targets in NSCLC.

a qRT-PCR results of miR-519d-5p in NSCLC tissues (n = 20). b Kaplan–Meier plot analysis of miR-519d-5p levels with the overall survival of patients with squamous carcinoma (LUSC). c, d qRT-PCR analysis of CD47 and TIPRL in NSCLC tissues (n = 20). e Immunohistochemistry showed cd47 and TIPRL levels are high in NSCLC tissues versus adjacent control, bar = 125 μm (upper); bar = 50 μm (below). f Kaplan–Meier plotter analysis of CD47 and TIPRL expression with the overall survival of patients with NSCLC (LUSC). g Proposed model by which miR-519d-5p, regulated by KCTD21-AS1, promoted the phagocytic function of macrophages and suppressed lung cancer cell proliferation. Data were shown as median (interquartile range), **p < 0.01, Mann–Whitney U test.