Fig. 3: The maintenance of MCM equilibrium by parental and nascent MCM helicases. | Communications Biology

Fig. 3: The maintenance of MCM equilibrium by parental and nascent MCM helicases.

From: Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity

Fig. 3

a Daughter cells inherit from their mothers both MCM pools. In the subsequent S phase, parental MCMs are preferentially converted to active replisomes, while nascent MCMs remain largely inactive but act as natural replisome pausing sites needed to adjust physiological replication fork progression. b During origin licensing in daughter cells, parental and nascent MCMs are loaded on chromatin in an ~1:2 ratio. The graph presents a general scheme that is based on findings in ref. 44.

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