Fig. 4: SHMT2 deficiency worsens fatty liver but improves AMLN diet response by reducing inflammation and fibrosis.
From: SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice
a Eco-MRI measured HKO and fl/fl mice’s body composition after 18 weeks on AMLN diet at 22 weeks old (Mean ± SD; *p < 0.05, **p < 0.01; t-test). b The levels of total triacylglycerol (TG) and total cholesterol (TC) in mouse circulation after 18 weeks on AMLN diet. (Mean ± SD; *p < 0.05; t-test). c The levels of TG and TC in mouse livers after 18 weeks on AMLN diet. (Mean ± SD; *p < 0.05; t-test). d Glucose tolerance test conducted on mice after 14 weeks on AMLN diet (Mean ± SD; n = 6; ***p < 0.001; t-test). e Insulin sensitivity test conducted on mice after 16 weeks on AMLN diet. (Mean ± SD; n = 6; *p < 0.5; t-test). f H&E (left), Oil Red O (middle), and Sirius Red (Right) staining of mouse liver sections after 18 weeks on AMLN diet. Scale bar: 100 μm. g Pathological grading of liver steatosis (left), lobular inflammation (middle), and fibrosis (right). (Mean ± SD; *p < 0.05, **p < 0.01; t-test). h Levels of ALT in circulation (Mean ± SD; **p < 0.01; t-test).
