Fig. 6: Alteration of force and calcium transients under high mechanical preload.

a Normalized average contraction force and calcium and force-calcium loops in human myocardial slices under high preload (5000 µN, n = 3 patients, 6 slices). b Amplitude (difference between peak and baseline values), Ton, and tau in force and calcium transients under high preload (n = 3 patients, 6 slices). Data presented as mean and SEM. Statistical differences were calculated with paired Student t test with a significance cutoff of p < 0.05.